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KMID : 0861019990140020097
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Korea Journal of Herbology
1999 Volume.14 No. 2 p.97 ~ p.103
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Neuroprotective Effects of Uncariae Ramulus et Uncus on the Brain Ischemia induced by Four - Vessel Occlusion in Rats
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ì°ìÒüº/Lee, In-Hwan
ì÷ˬúè/ì°ñ£à¸/à´ÌÒûÇ/äÌÓìг/ÚÓûÛÏÖ/±èûáôÉ/Leem, Kang-Hyun/Lee, Jong-Seok/Suk, Kyoung-Ho/Ahn, Duk-Kyun/Kim, Ho-Cheol/Park, Ho-Koon
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Abstract
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Uncariae Ramulus et Uncus(UR, ???) has sweet in flavour and slightly cold in property, acting on the liver and pericardium channels. This drug was described in a medical classic as having the ability to remove "heat", check hyperfunction of the liver and relieve dizziness, tremors, and convulsion, and subdue "endogenous wind". So this study was planned to check the neuroprotective effect of UR on the global ischemia induced by 4-vessel occlusion in Wistar rats. and UR extract was lyophilized after extraction with 70% methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining.
In 4-VO ischemia model, UR showed significantly neuroprotective effects(1,000 and 500 §·/§¸ of UR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about 23.0%, 19.0% respectively. Consequently, Uncariae Ramulus et Uncus has neuroprotective effects on the global ischermia induced by 4-vessel occlusion in Wistar rats. So we expect that Uncariae Ramulus et Uncus can be used as a drug for neurodegenerative disease.
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